Electron microscopic evidence for the association of M 2 protein with the influenza virion
Identifieur interne : 002054 ( Main/Exploration ); précédent : 002053; suivant : 002055Electron microscopic evidence for the association of M 2 protein with the influenza virion
Auteurs : D. C. Jackson [Australie] ; Xi-Lin Tang [Australie] ; K. Gopal Murti [États-Unis] ; R. G. Webster [États-Unis] ; G. W. Tregear [Australie] ; W. J. Bean [États-Unis]Source :
- Archives of Virology [ 0304-8608 ] ; 1991-09-01.
English descriptors
- Teeft :
- Amino, Amino acid sequence, Amino acids, Antibody binding, Antigenic, Antiserum, Avian, Avian strains, Avian viruses, Chalmers virions, Direct evidence, Fowl plague virus, Grid, Human viruses, Immunoelectron microscopy, Immunogold electron microscopy, Influenza, Influenza virion, Influenza virions, Influenza virus, Influenza virus hemagglutinin, Influenza viruses, Intact virions, Intact virus, Lysed virions, Monoclonal antibodies, Mouse antiserum, Peptide, Peptide synthesis, Proc natl acad, Rabbit antiserum, Second protein, Significant levels, Similar dose, Synthetic peptide, Virion, Virology, Virus.
Abstract
Summary: Immunogold electron microscopy revealed that site-specific antibodies elicited by a synthetic peptide representing the N-terminal sequence (residues 2–10) of influenza virus M 2 protein were capable of binding to the surface of virions. Antibody binding was observed with two human influenza virus strains but not with an avian virus strain which has amino acid substitutions in the appropriate sequence of M 2. These results provide direct evidence for the presence of M 2 in the influenza virion.
Url:
DOI: 10.1007/BF01314030
Affiliations:
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Antibody binding was observed with two human influenza virus strains but not with an avian virus strain which has amino acid substitutions in the appropriate sequence of M 2. These results provide direct evidence for the presence of M 2 in the influenza virion.</div></front></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country><region><li>Tennessee</li><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Jackson, D C" sort="Jackson, D C" uniqKey="Jackson D" first="D. C." last="Jackson">D. C. Jackson</name></region><name sortKey="Tang, Xi Lin" sort="Tang, Xi Lin" uniqKey="Tang X" first="Xi-Lin" last="Tang">Xi-Lin Tang</name><name sortKey="Tregear, G W" sort="Tregear, G W" uniqKey="Tregear G" first="G. W." last="Tregear">G. W. 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